Saxitoxin（Saxitoxin Acetate） 蛤蚌毒素（石房蛤毒素）
Description （STX） is a neurotoxin isolated from marine dinoflagellates
Alexandrium tamarense. It is a selective sodium channel blocker. The medical importance of saxitoxin is in relation to red tide in shellfish and causes the paralytic shellfish poisoning （PSP）. The blocking of the sodium channel produces a flaccid paralysis that leaves its victim calm and conscious through the progression of symptoms. Death is from respiratory failure. has been an important tool in cellular research in describing the function of the sodium channel.
Molecular weigh 419.39 Molecular formula C10H17O4 ·2C2H4O2
Case Number 220355-66-8 Solubility MeOH, EtOH or DMSO
Storage Stable in -25 oC for 2 year
Form Lyophilized solid Lyophilized solid
Appearance（color） White to off-White White
Purity ≥ 95% by HPLC ≥ 95%
Method: Liquid chromatography with post-Column oxidation and
fluorescence detection
Material: （STX） 10μg/ml
Column: Cosmosil C18-MS 5μm, 4.6x250mm
phase: 2mM NaHSA in 30mM NH4H2PO4 （pH 7.1）:CH3CN=93:7
Flow rate: 0.8 ml/min
Oxidation: 7mM HIO4 in 50mM K2HPO4 （pH9）
Coil reaction: 10m Teflon tubing （0.3 mm i.d.） at 85℃
Effluent acidified: 0.5M CH3COOH 0.25ml/min
Detection: Fluorescence, Ex. 330nm, Em. 390nm
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