Rabbit Anti-CYP2D6抗體說(shuō)明書

Cat. Number:  Rs-1027R  

Quantity size:  0.1ml  （dilute with pH 7.4    0.01 M PBS or diluent of antibody）

Background: commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" （LKM 1）.
Also known as: Cytochrome P450 2D6; CPD6; CYP2D; CYP2D6; CYP2DL1; CYPIID6; Cytochrome P450 family 2 subfamily D polypeptide 6; Debrisoquine 4 hydroxylase; EC 1.14.14.1; Flavoprotein linked monooxygenase; MGC120389; MGC120390; Microsomal monooxygenase; P450 DB1; P450C2D; P450DB1; Xenobiotic monooxygenase.

Specificity:      ·  anti- CYP2D6 is a rabbit monoclonal antibody unconjugated

 ·  specific for CYP2D6 of human, rat,mouse and chicken  

  · epitope mapping near the C terminus of CYP2D6 of human, rat mouse

and chicken

· human, rat, mouse and chicken cross reacted    

·  use for western blotting, elisa, immunoprecipitation    

   and immunohistochemistry

·  Protein A affinity chromatography purification, purity :>95%

· Isotype: IgG   · mol wt: 48kDa

Application:     · Western blotting: 1:100-500

· Immunohistochemistry: 1:100-500

· ELISA: 1:500-1000

·  Optimal working dilutions must be determined by the end user.

Storage:   Store at –20 ºC for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20ºC. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ºC.

Important Note:  This product as supplied is  intended for research use only, not for use in human, therapeutic or diagnostic applications.

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