Anti-RIM2抗體,神經(jīng)元突觸膜胞外分泌調(diào)節(jié)蛋白2抗體

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博研生物強烈*“Anti-RIM2抗體,神經(jīng)元突觸膜胞外分泌調(diào)節(jié)蛋白2抗體"，品質(zhì)保障，*，提供，實驗無結(jié)果可免費退換?。?/p>

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Anti-RIM2抗體,神經(jīng)元突觸膜胞外分泌調(diào)節(jié)蛋白2抗體產(chǎn)品介紹：Rab3, a neural/neuroendocrine-specific member of the Rab family, is involved in Ca2+-regulated exocytosis (1-2). Rab3 functions in an inhibitory capacity by controlling the recruitment of secretory vesicles into a releasable pool at the plasma membrane. Rim (rab3 interacting molecule), a putative effector protein for Rab3s, is composed of an amino-terminal zinc-finger motif and carboxy-terminal PDZ and C2 domains. Rim exists as two variants, Rim1 and Rim2, produced by alternative splicing (3). Rim1 is expressed near the active zone at the synapse, where it interacts in a GTP-dependent manner with Rab3, located on synaptic vesicles (4). Therefore, Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles (5). Both Rim1 and Rim2 can bind to cAMP-GEFII, which is a direct target of cAMP in regulated exocytosis and is responsible for cAMP-dependent, PKA-dependent exocytosis (3). Rim also localizes on the plasma membrane of INS-1E cells and pancreatic beta-cells. Rab3 binding domain of Rim enhances glucose-stimulated secretion in intact cells and Ca2+-stimulated exocytosis in permeabilized cells, suggesting that Rim may also play a regulatory role in insulin secretion (6).

保存條件: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃

重要提示: 本產(chǎn)品提供僅供研究使用，不用于人類治療或診斷.

產(chǎn)品名稱：Anti-RIM2抗體,神經(jīng)元突觸膜胞外分泌調(diào)節(jié)蛋白2抗體

產(chǎn)品編號：BYK-11357R

產(chǎn)品規(guī)格：0.1ml/0.2ml

產(chǎn)品價格：請

性狀：Lyophilized or Liquid

濃度：1mg/1ml

亞型：IgG

貯存：貯存于-20℃.

抗體來源：本公司抗體有兔來源和鼠來源等

克隆類型：兔來源為多抗，鼠來源為單抗

產(chǎn)品類型：一抗

此抗體本公司有單抗和多抗，可用于免疫組化（IHC），免疫印跡（WB），酶聯(lián)免疫(ELISA)，IF、IP、流式細胞術等實驗（可來電索取說明）

此產(chǎn)品本公司有標記的一抗出售，相關標記有：Alexa Fluor 350 標記、Alexa Fluor 488 標記、Alexa Fluor 555 標記、Alexa Fluor 647 標記、AP標記、APC標記、Biotin標記、Cy3標記、Cy5標記、Cy5.5標記、Cy7標記、FITC標記、Gold標記、HRP標記、PE標記、PE-Cy3標記、PE-CY5標記、PE-CY5.5標記、PE-CY7標記、RBITC標記

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