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聯(lián)系我時,請告知來自 環(huán)保在線博研生物強烈*“Anti-HFE抗體,遺傳性血色病蛋白相關(guān)蛋白1抗體免疫實驗",品質(zhì)保障,*,提供,實驗無結(jié)果可免費退換?。?/p>
Anti-HFE抗體,遺傳性血色病蛋白相關(guān)蛋白1抗體免疫實驗介紹:The features of hemochromatosis include cirrhosis of the liver, diabetes, hypermelanotic pigmentation of the skin, and heart failure. Since hemochromatosis is a relatively easily treated disorder if diagnosed, this is a form of preventable cancer. The HFE protein, which is defective in hereditary hemo-chromatosis, normally is expressed in crypt enterocytes of the duodenum where it has a unique, predominantly intracellular localization. In placenta, the HFE protein co-localizes with and forms a stable association with the transferrin receptor (TfR), providing a link between the HFE protein and iron transport. Immunocytochemistry shows that the HFE protein and TfR both are expressed in the crypt enterocytes. Western blots show that, as is the case in human placenta, the HFE protein in crypt enterocytes is physically associated with the TfR and with β2-microglobulin. It is proposed that HFE has two mutually exclusive activities in cells: inhibition of uptake or inhibition of release of iron and that the balance between serum transferrin saturation and serum transferrin-receptor concentrations determines which of these functions predominates. The gene which encodes HFE maps to human chromosome 6p21.3l.
相關(guān)的標(biāo)記有:Alexa Fluor 350 標(biāo)記、Alexa Fluor 488 標(biāo)記、Alexa Fluor 555 標(biāo)記、Alexa Fluor 647 標(biāo)記、AP標(biāo)記、APC標(biāo)記、Biotin標(biāo)記、Cy3標(biāo)記、Cy5標(biāo)記、Cy5.5標(biāo)記、Cy7標(biāo)記、FITC標(biāo)記、Gold標(biāo)記、HRP標(biāo)記、PE標(biāo)記、PE-Cy3標(biāo)記、PE-CY5標(biāo)記、PE-CY5.5標(biāo)記、PE-CY7標(biāo)記、RBITC標(biāo)記
保存條件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹:
產(chǎn)品名稱:Anti-HFE抗體,遺傳性血色病蛋白相關(guān)蛋白1抗體免疫實驗
產(chǎn)品編號:BYK-12335R
英文名稱 HFE
中文名稱 遺傳性血色病蛋白相關(guān)蛋白1抗體
別 名 dJ221C16.10.1; Hemochromatosis; Hemochromatosis protein; Hereditary hemochromatosis protein; Hereditary hemochromatosis protein HLA H; HFE 1; HFE; HFE_HUMAN; HFE1; HH; High Fe; HLA H; HLA-H; HLAH; MGC:150812; MGC10379; MGC103790; MHC class I like protein HFE; MVCD7; TFQTL2.
研究領(lǐng)域 腫瘤 心血管 細胞生物 神經(jīng)生物學(xué) 糖尿病 新陳代謝
分 子 量 38kDa
細胞定位 細胞膜
產(chǎn)品價格:詢價(電詢或客服)
抗體來源:本公司抗體有兔來源和鼠來源等
克隆類型:兔來源為多抗,鼠來源為單抗
產(chǎn)品類型:一抗
產(chǎn)品用途:科研實驗
性 狀: Lyophilized or Liquid
濃 度: 1mg/1ml
亞 型: IgG
貯 存: 貯存于-20℃.
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