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Anti-HCV-NS4a抗體,丙型肝炎病毒-NS4a抗體

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博研生物強(qiáng)烈*“Anti-HCV-NS4a抗體,丙型肝炎病毒-NS4a抗體",品質(zhì)保障,*,提供,實(shí)驗(yàn)無結(jié)果可免費(fèi)退換!:

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     Anti-HCV-NS4a抗體,丙型肝炎病毒-NS4a抗體介紹:Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis).

相關(guān)的標(biāo)記有:Alexa Fluor 350 標(biāo)記、Alexa Fluor 488 標(biāo)記、Alexa Fluor 555 標(biāo)記、Alexa Fluor 647 標(biāo)記、AP標(biāo)記、APC標(biāo)記、Biotin標(biāo)記、Cy3標(biāo)記、Cy5標(biāo)記、Cy5.5標(biāo)記、Cy7標(biāo)記、FITC標(biāo)記、Gold標(biāo)記、HRP標(biāo)記、PE標(biāo)記、PE-Cy3標(biāo)記、PE-CY5標(biāo)記、PE-CY5.5標(biāo)記、PE-CY7標(biāo)記、RBITC標(biāo)記 

保存條件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.


產(chǎn)品介紹:

產(chǎn)品名稱:Anti-HCV-NS4a抗體,丙型肝炎病毒-NS4a抗體
產(chǎn)品編號(hào):BYK-0213R

英文名稱 HCV-NS4a
中文名稱 丙型肝炎病毒-NS4a抗體
別    名 HCV-NS4a; Non-structural protein 4A; NS4A; POLG_HCVBK; p8.
研究領(lǐng)域 細(xì)菌及病毒  
分 子 量 5kDa
細(xì)胞定位 細(xì)胞漿 細(xì)胞膜 
  

產(chǎn)品價(jià)格:詢價(jià)(電詢或客服)
抗體來源:本公司抗體有兔來源和鼠來源等
克隆類型:兔來源為多抗,鼠來源為單抗
產(chǎn)品類型:一抗
產(chǎn)品用途:科研實(shí)驗(yàn)
性 狀:   Lyophilized or Liquid
濃 度:   1mg/1ml 
亞 型:   IgG
貯 存:   貯存于-20℃.


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