Cat. Number:  Rs-1027R  

Quantity size:  0.1ml （dilute with pH 7.4    0.01 M PBS or diluent of antibody）

 

Background: commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrythmic drugs; and amitryptiline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Cytochrome P450 2D6 is the molecular target of autoantibodies against the "liver kidney microsomal antigen 1" （LKM 1）.

 

Also known as： Cytochrome P450 2D6; CPD6; CYP2D; CYP2D6; CYP2DL1; CYPIID6; Cytochrome P450 family 2 subfamily D polypeptide 6; Debrisoquine 4 hydroxylase; EC 1.14.14.1; Flavoprotein linked monooxygenase; MGC120389; MGC120390; Microsomal monooxygenase; P450 DB1; P450C2D; P450DB1; Xenobiotic monooxygenase.

CYP2D6抗體說明書

Specificity:      · anti- CYP2D6 is a rabbit monoclonal antibody unconjugated

 · specific for CYP2D6 of human, rat,mouse and chicken  

 · epitope mapping near the C terminus of CYP2D6 of human, rat mouse

and chicken

· human, rat, mouse and chicken cross reacted    

· use for western blotting, elisa, immunoprecipitation    

   and immunohistochemistry

· Protein A affinity chromatography purification, purity :>95%

· Isotype: IgG   · mol wt: 48kDa

Application:     · Western blotting: 1:100-500

· Immunohistochemistry: 1:100-500

· ELISA: 1:500-1000

· Optimal working dilutions must be determined by the end user.

 

Storage:   Store at –20 ºC for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20ºC. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ºC.

 

Important Note: This product as supplied is intended for research use only, not for use in human,  therapeutic or diagnostic applications.